4.3 Mitophagy and metabolic-associated fatty liver diseases Metabolic associated fatty liver disease (MAFLD) refers to a series of diseases caused by multi-systemic metabolic dysfunction resulting in chronic liver damage, including hepatic steatosis, NAFLD, hepatic fibrosis, liver cirrhosis, hepatocellular carcinoma, and others ( In vitro , CP upregulates the protein levels of PGC-1, PPAR, PINK1, Parkin, ATG7, and LC3I/II in free FA (FFA)-induced NAFLD cell models, activates the PINK1-Parkin signaling pathway to promote mitophagy in liver cells, and inhibits FFA-induced OS and lipid accumulation
Li FJ, Abudureyimu M, Zhang ZH, Tao J, Ceylan AF, Lin J, Yu W, Reiter RJ, Ashrafizadeh M, Guo J, Ren J (2024) Inhibition of ER stress using tauroursodeoxycholic acid rescues obesity-evoked cardiac remodeling and contractile anomalies through regulation of ferroptosis
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in fact, poor tolerability was encountered in only 3.9% of patients, whereas 1.6% discontinued treatment due to treatment-related adverse events [46]
Gillani SW et al
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