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Perhaps this administration method extends to the upper range of the estimated oral bioavailability (19-20%)

In new research from Stefano Comai et al., mice who were genetically altered to have no M1 receptor (MT1KO knockout mice) showed a decrease in rapid eye movement (REM) sleep, which is linked to dreaming, and an increase in slow wave (or deep) sleep

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Moreover, our findings are likely generalizable to the majority of individuals with T2D who are treated with non-intensive treatments and have sub-optimally controlled A1c