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50 Evidence strongly suggests that GLP-1 increases ER-mitochondria communication, resulting in higher mitochondrial activity

[DOI] [PubMed] [Google Scholar] [15].Fannin SW, Lesnefsky EJ, Slabe TJ, Hassan MO, Hoppel CL

The dual GIP/GLP-1 mechanism appears to enhance insulin sensitivity and fat oxidation beyond what GLP-1 alone provides

TLR5 is expressed in certain non-myeloid cells (e.g., epithelial and endothelial cells) and myeloid cells (e.g., alveolar macrophages and neutrophils)

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Consistent with this metabolic reprogramming, our study revealed significantly elevated plasma glutamic acid levels in EP, which is in agreement with earlier reports of its accumulation in this population 17