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Therefore, as shown in Figure S5 , for a given pKa of niclosamide of 6.87, the position of this curve, that delineates the amount of niclosamide in solution across the whole pH range, is determined by the value for NIC OH , the low solubility acid, which, again, is measured here to be 1.77uM

Brain 136 , 872881 (2013)

Six major degradation products were identified, resulting from modifications to the AFB1 structure, particularly in the furofuran ring, cyclopentenone, and methoxy group

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This often results in poor texture of the skin and becomes a reason behind the appearance of dryness and roughness, which leads to premature aging