Individuals with methylation issues, such as those with MTHFR variants, might respond differently to NNMT inhibition
[2] Patients should contact their GP if they experience: Side effects from B12 injections (though these are rare and usually mild) Difficulty attending scheduled injection appointments, as missed doses may lead to symptom recurrence New symptoms developing during treatment Concerns about treatment effectiveness or duration Changes in other medications that might affect B12 absorption Suspected adverse reactions to B12 treatment can be reported through the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)
For example, concurrent use of chloramphenicol (an antibiotic) may attenuate the hematologic response to vitamin B therapy
The compound did not affect fasting glucose, insulin, HbA1c, IGF-1, cortisol, thyroid hormones, or liver enzymes (Thompson et al., 2004)
Muscle weakness
But youve gotta give it time to build up enough B12 reserves first