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It is being studied for the treatment of type 2 diabetes and obesity

Methionine and choline are generally more stable but can still be affected by prolonged heat exposure

The American Association of Endocrinologists and American College of Endocrinology's recommendations list GLP-1 receptor agonists as the preferred add-on to metformin, followed by SGLT2 inhibitors and DPP-4 inhibitors as preferred oral add-on options