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doi: 10.1177/20406223221076890 235 DeMarsJBrownDAAngelidisIJonesFMcGuireFOBrienKKet al

Do not use GLP-1 medication that has been frozen, even after thawing, as freezing causes irreversible damage to the protein structure

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The number needed to treat to prevent one death over three years was 39

A positive effect was also observed on systolic blood pressure

Rare but serious risks include pancreatitis, gallbladder disease, and a thyroid C-cell tumor risk based on rodent studies (semaglutide carries a boxed warning and is contraindicated in patients with personal or family history of medullary thyroid carcinoma or MEN2)