16 CheF.WangG.YuJ.WangX.LuY.FuQ.et al (2017)
Melting point: mp 200 (dec) (Marzi) Optical Rotation: [ a ] D25 -31.3 (c = 10 in water)
Theobromine for treatment of uric acid stones and other diseases
The following CVOTs, relative to DPP-4i and GLP-1RAs, have been identified and included in this review: EXAMINE, SAVOR-TIMI53, TECOS, CARMELINA, CAROLINA, ELIXA, SUSTAIN 6, EXSCEL, HARMONY, LEADER, PIONEER 6, REWIND, and AMPLITUDE-O [4749, 53, 54, 5663]
You should contact your GP or healthcare provider if you experience: Persistent green stools lasting more than a week without obvious dietary explanation Black, tarry stools (melaena), which may indicate upper gastrointestinal bleeding Bright red blood in stools (haematochezia) or on toilet paper Pale, clay-coloured, or white stools , which could suggest bile duct obstruction or liver problems Diarrhoea lasting more than 48 hours , particularly if accompanied by dehydration symptoms Severe abdominal pain , especially if localised to the upper abdomen and radiating to the back, which could indicate pancreatitis (a rare but serious side effect of GLP-1 receptor agonists) Right upper quadrant pain , particularly after fatty meals, which may suggest gallbladder problems Yellowing of the skin or eyes (jaundice) with dark urine, which could indicate liver or gallbladder issues Signs of dehydration: excessive thirst, dark urine, dizziness, reduced urination, or dry mouth Persistent vomiting preventing adequate fluid or medication intake Unexplained weight loss beyond expected therapeutic effects Fever accompanying stool changes , suggesting possible infection For urgent but non-emergency concerns, contact NHS 111
doi: 10.1038/nrgastro.2017.119 59 FiorucciSMarchianSUrbaniGDi GiorgioCDistruttiEZampellaAet al
