Maybe a board certified cardiologist can tell from x-rays (rads) alone that the LA or LV is enlarged, but as we noted above, even they will disagree from time to time, and especially if the positioning of the dog (even flexing the neck can cause misleading shadowing) and quality of the films are less than perfect, or the dog was inhaling in one view and exhaling in another or sedated in one and not in the other
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FDA announcement: Repost to share the nuanced reality of oral GLP-1s
Published literature describes: In-vitro cellular assays:Peptide concentrations typically range from nanomolar to low micromolar levels, depending on cell type and signaling endpoints measured Receptor binding studies:Concentrations optimized for kinetic and competitive binding analysis Preclinical animal models:Variable dosing based on animal species, route of administration, study duration, and specific biological parameters evaluated How should MT-1 be stored and handled
doi: 10.1111/dom.12593 4 HusseinHZaccardiFKhuntiKDaviesMJPatskoEDhalwaniNNet al
A dosing chart designed for 10mg/mL concentration will overdose by 100% if applied to a 20mg/mL vial, or underdose by 50% if applied to a 5mg/mL vial