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Despite this, in this review, we consider evidence from both therapeutic dosing and overdose studies because pre-clinical data suggest everyone would develop liver injury if the dose of paracetamol was sufficiently high for that individual

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The content of trigonelline decreases continuously throughout roasting, while nicotinic acid and N methylpyridinium increases, with N-methylpyridinium being the major thermal product up to the dark medium roast, similar to the Purity Dark Roast