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Given the relatively disappointing outcomes from clinical trials directed towards modulating IGF1R signaling, there is reason to hope that an alternative approach to regulating this network of oncogenic pathways may come from regulating the ligands and their regulatory binding proteins, some of which also act through mechanisms independent of IGF1R signaling

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et Perryman, N.C., Properties and purification of adipose tissue lipase , J

Dai FC, Wang P, Li Q, Zhang L, Yu LJ, Wu L, et al

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