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The 20252026 trend is strongly toward excluding or restricting weight-loss GLP-1s: Florida Blue excludes them under a standing policy, Independence Blue Cross and BCBS of Michigan dropped them in 2025, and Blue Shield of California restricts new starts to BMI 40 or higher

Moulton CD, Hopkins CWP, Ismail K, Stahl D

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Pflugers Arch - Eur J Physiol 472 , 13851399 (2020)

Retatrutide, a GIP, GLP-1, and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial

GH also raises levels of insulin-like growth factor-1 (IGF-1)