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Signal transduction in astrocytes during chronic or acute treatment with drugs (SSRIs, antibipolar drugs, GABA-ergic drugs, and benzodiazepines) ameliorating mood disorders
Receptor-/transporter-mediated brain-targeting Modifying the surface of a nanoparticle with a brain-targeting agent is often utilized to turn a nanoparticle drug delivery system into a brain targeting nanoparticle drug delivery system
Research systematically characterising the structure-activity relationships of Thymosin Beta-4 through deletion and substitution analysis validated TB-500s sequence as the minimal active fragment retaining full biological activity and confirming that the 17 amino acid actin-binding domain peptide reproduces the wound healing, cell migration, and angiogenic effects of intact Thymosin Beta-4 in relevant assay systems
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Considering the promising performance of C-KIT inhibitors in MM, now more efforts have been focused on the understanding of the acquired resistance mechanism and the development of new blocking agents to overcome resistance, offering hope for patients with advanced MM and limited treatment options
