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The patient who needs rapid, clinically significant weight loss for diabetes management is not the same patient as the one who wants to reduce visceral fat while preserving the lean mass they have built over years of training

Working in concert with the CNS and sympathetic ganglia, 41 it plays a key role in integrating local gastrointestinal information, allowing for significant autonomy in gut function

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The Oxford University 2026 study found that patients who stopped tirzepatide regained an average of 0.8 kg per month, with most returning to their pre-treatment baseline weight within approximately 18 months

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