Male Sprague-Dawley rats (Taconic derived) weighing 390-450 g were maintained with free access to water and food (Harland Tekland F6 rodent diet, Madison, WI) except the night prior to surgery when food was removed
8 However, in the isolated perfused rat kidney, Ang A induced dose-dependent vasoconstriction, which was abolished by AT 1 receptor blockade, but not by the AT 2 receptor antagonist PD123319 (ref
Collagen synthesis, angiogenesis, and gene expression repair do not occur after a single dose
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