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Klebsiella aerogenes, identified in some IBS patients' microbiota and carrying a histidine decarboxylase gene, is a major producer of histamine [57]

In comparison, direct NSP inhibitors have rapid onset but may require more frequent dosing and have limited inhibitory effects on high-concentration NSPs at inflammatory sites

Nitric oxide (NO) is an example of a vasodilator , a substance that causes blood vessels to dilate, thereby increasing blood flow

The peptide also demonstrates effects on various growth factors and cytokines, including upregulation of laminin-5 and promotion of keratinocyte migration, contributing to wound healing processes

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Additionally, efforts have been made to standardize and manage the quality control of Hymenoptera venom, including BV, to ensure its therapeutic efficacy (Oliveira Orsi et al., 2024)