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Evidence Rating Level: 1 (Excellent) Study Rundown: Psoriatic arthritis (PsA) affects approximately up to 30% of patients with a history of psoriasis

It activates the tyrosine kinase activity of IGF-1 receptor (IGF-1R), induces downstream MAPK/ERK and PI3K/Akt pathways, promotes the expression of cell cycle proteins (Cyclin D1, E), and accelerates the transition of cells from G1 phase to Sphase