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290 Activated PARP1 also possesses a transcription-regulatory function, promoting the induction of DNA repair factors by E2F1 and enhancing the progression to treatment-resistant cancer

The honest answer is that it depends on the individual

Tell your healthcare provider if you have any signs or symptoms of a urinary tract infection, such as a burning feeling when passing urine, a need to urinate often, the need to urinate right away, pain in the lower part of your stomach (pelvis), or blood in the urine

Retrieved from Avraham SA, Hossein J, Somri F, Hawash N, Hochman O

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The delayed gastric emptying may affect absorption of oral medications, including oral contraceptives, potentially requiring additional contraceptive measures