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For example, the LEADER trial showed that Liraglutide significantly reduced the risk of major adverse cardiovascular events (MACE) by 13% and cardiovascular death by 22% in comparison to placebo

Clinical studies show that lower doses of GLP-1 agonists are highly effective at reducing hemoglobin A1c (which indicates the average blood sugar level over the past 2-3 months), improving insulin sensitivity, and directly addressing the metabolic dysregulation often associated with estrogen decline and perimenopausal weight gain, helping to stabilize energy levels and reduce fat-storage signaling

Second, although this analysis included 45 studies with a fairly large sample size, the low incidence of thyroid events resulted in a wide confidence interval that reduced the certainty of our findings

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