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High mobility group box 1 (HMGB1), RAGE, TLR4, NF-B and pNF-B expression reduction in mouse skin tissues and the decreased expression of pro-inflammatory cytokines TSLP, IL-4, IL-6, IL-13, IL-31 and TNF- was also observed [190]

The etiological and pathological mechanism of drug-induced AP remains unclear

2,18 Treatment The treatment of functional constipation requires parental education, behavior interventions, measures to ensure that bowel movements occur at normal intervals with good evacuation, close follow-up, and adjustment of medication and evaluation as necessary

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Refrigerate after reconstitution, or freeze at -20C for long-term storage

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