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In these cases, SAMe, either acting as a methyl group donor, or a mediator of specific enzyme activity, has augmentative effects on MMD treatments

Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits

Zeng H, et al

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