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Chang Q, Gold PE

As an example, during the evaluation of a patient whose primary phenotype was attention-deficit/hyperactivity disorder (ADHD), an incidental finding revealed a pathogenic nonsense mutation in SCN5A , associated with Brugada syndrome

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Authors' contributions HN, MR, JJ, and CM formulated the questions and contributed substantially to the design of the project

Heartburn that doesnt respond to any of the above measures and is occurring daily, pain or difficulty swallowing, a sensation of food getting stuck, unexplained weight loss beyond what the medication accounts for, or heartburn accompanied by chest pain that radiates to the arm or jaw are all symptoms requiring medical evaluation rather than self-management