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Drug Metab Dispos 2020;48:326-36

The increased pressure in the superior sagittal sinus, portal and caval hypertension, aortal hypotension, arterial and venous thrombosis, severe brain swelling and lesions (cortex (cerebral, cerebellar), hypothalamus/thalamus, hippocampus), particular veins (azygos, superior mesenteric, inferior caval) dysfunction, heart dysfunction, lung congestion as acute respiratory distress syndrome, kidney disturbances, liver failure, and hemorrhagic lesions in gastrointestinal tract were all assessed

Common functional variants at G6PD have independently arisen on diverse genetic backgrounds across a wide geographic range and exhibit variable penetrance with respect to enzyme activity

Its also the only vetted program offering a structured microdosing option lower-dose protocols designed for gentler titration, which matters for medication-sensitive patients