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As well as when patients with -thal were exogenously supplemented with vitamin E, researchers found that antioxidants could mitigate oxidative stress in erythrocytes through multiple targets, thereby impacting iron overload ( On the other hand, iron overload may also be an intermediate link in the interaction between ferroptosis and, IE in -thal

Adding a medication that further reduces BMD compounds an existing vulnerability

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Patients with Se deficiency can benefit from Se supplementation, while Se supplementation in people with adequate Se levels can exacerbate the risk of certain diseases (3)

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This interaction may explain observed improvements in mood, reduced substance cravings, and changes in compulsive food-seeking behavior