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Its caused by inflammation and micro-damage to the muscles, tendons, and bone tissue in the lower leg, usually resulting from repetitive stress or overuse

notes that a significant number of people who are B12 deficient are unable to absorb the vitamin from food or supplements, and so need to inject it, which they can only do at their GP practice

Ensuring adequate B vitamin levels removes nutritional barriers to nerve repair

M.RossellaD

The Neelakantan 2018 paper showed strong oral absorption in cell uptake (Caco-2) assays, which is why most research community use is by mouth instead of by injection

Studies highlight its applications in metabolic research, weight management studies, and insulin sensitivity research