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These medicines play an important role in the liver detoxification and pigment lightening

In the kidney, we observed widespread disruption in energy metabolism and multiple molecules involved in glycolysis, gluconeogenesis, and the TCA cycle were depleted, indicating a more global disruption in energy metabolism than has been previously appreciated

Lifestyle adaptation can further contribute to reduced treatment response

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From a clinical standard of care perspective , most obesity medicine guidelines recommend monthly follow-ups for the first 3 months (especially when titrating GLP-1 doses), then every 2-3 months once stable