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The approval stems from the Phase IIIb SOUL trial involving over 9,600 patients, which showed MACE occurred in 12% of Rybelsus-treated patients versus 13.8% on placeboa statistically significant 14% treatment effect

Clinical studies have shown that patients who reach and maintain their target dose typically achieve 15-20% greater weight loss compared to those who remain at lower doses

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TGF-beta receptor 1 regulates progenitors that promote Browning of white fat