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GLP-1s work by engaging the reward systems of the brain and endocrine system, effectively suppressing the dopamine reward for impulsive behavior, making those behaviors less and less appealing

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It activates lysyl oxidase, an enzyme that crosslinks collagen fibers to create strong scar tissue

KandelDBojsen-MollerKNSvaneMSSamkaniAAstrupAHolstJJet al

In the era this article has been describing, where five distinct axes each have a leading molecule and the right answer for any given patient depends on which axis they actually need to optimize, the genetic question stops being interesting and starts being practical

Omar, Elmesallamy, and Eassa 2005