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Understanding whether tirzepatide burns fat or just suppresses appetite and whether tirzepatide increases metabolism helps calibrate realistic expectations about the mechanism

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If nausea arises when GLP-1 RA plasma concentrations are at their peak, then continuous exposure to GLP-1 RAs may lead to tachyphylaxisa reduced response to the drug over timeresulting in fewer gastrointestinal symptoms after long-term use [20]

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Add one new peptide per week, document your response, and only add the next when the current one is well tolerated

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Historically, glucose lowering agents approved for management of T2D in patients with advanced CKD have been limited to insulin and sulfonylureas despite their associated risk of hypoglycemia and neutral effect on cardiovascular outcomes or progression of kidney disease 9

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