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Less body fat means a different volume of distribution for the medication

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Such buffering could for example be mediated by activation of the Nrf2-Keap1-ARE pathway, which has been shown to be increased after polyphenol supplementation which in turn induces the expression of phase II detoxifying enzymes, responsible for reducing endogenous toxic metabolites [65]

Diabetes (2016) 65:1196207

Treat the low blood sugar first with 15 grams of fast-acting carbohydrates and recheck after 15 minutes

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