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Signs you should slow down the titration Extend your stay at the current dose by 2-4 additional weeks if you experience any of the following at the end of a standard 4-week period: Nausea persisting beyond the first 7 days after the last dose increase Vomiting more than twice per week Diarrhea lasting more than 10 days at the current dose Significant fatigue or weakness that does not improve with adequate nutrition and rest Weight loss exceeding 1.5% per week (too-rapid loss increases gallstone risk and muscle loss) Slowing the titration is not failure

Hydrate: Sip fluids throughout the day

Is your dose appropriate for your current body weight and genetic profile

Can be used occasionally for acute relief when stool is impacted near the exit

PlexusDx pricing remains flat regardless of dose escalation, following the principle that your dose may go up while your price won't

doi: 10.1021/bi401444n