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Given the lack of understanding regarding pathophysiological causal factors in IC/BPS and the consequence that treatment goals are to control symptoms to optimize QoL, the Panel judged that the most appropriate course was to preserve treatments as clinical choices as long as some efficacy for some patients was demonstrated and the risk of serious harms was low

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A vitamin B12 injection is administered in the upper arm, this treatment only takes a few moments, minimal downtime, and pain

3.2.1 PINK1/Parkin mediated mitophagy The pathway consisting of PINK1 and Parkin is a key participant in mitophagy, as well as the most common and classical pathway of autophagic mitochondria (Lazarou et al., 2015)

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