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PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC 50 of 4.8 nM in A549 cell line, sensitive to oncogenic mutations (no activity to Y1230C mutant)

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Surgical options may be required if the bend in the penis is too severe to allow for sexual intercourse, surgical methods include: Plication : This involves folding the normal tissue on itself on the unaffected side with sutures Grafting : This involves cutting out the scar and sewing in a piece of tissue (graft) to cover the holes in the tunica albuginea

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