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Specifically, metformin attenuates neointimal hyperplasia by inhibiting smooth muscle cell proliferation and migration through the insulin-signaling pathway by inhibiting the expression of advanced glycation end product (AGEs) receptors, which are related to cancer mortality through AMPK [21,22]
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Giugliani et al
So the real risk is this: Healthy older adults could be experimenting with GLP-1s and unintentionally shedding muscle mass at a time when they can least afford it possibly undermining any healthy aging benefits
This was not particularly surprising for researchers, as GLP-1 acts on the same brain regions that are involved in craving, reward, and motivation systems - largely driven by dopamine pathways
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