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Liang et al., 2018

GLP-1 (the "un-hunger hormone") is released in response to nutrients in your gut.* GLP-1 enters the bloodstream and interacts with organs, mainly the pancreas.* GLP-1 binds to pancreatic cells, promoting insulin release and impacting appetite and digestion.* GLP-1 helps you feel full and supports glucose metabolism

Patent CN105154498a example 10 discloses Arg34GLP-1 (9-37) main peptide chain is coupled with side chain with carboxyl protected by tert-butyl (tBu), then coupled with Boc-His (Boc) -Aib-OH dipeptide in presence of HATU and TEA, reaction time is as long as 14 days, freeze-drying time is as long as 16 hours after HPLC purification by post-treatment, which is not good for industrial production, and Boc has no strong absorption of Trt in ultraviolet, which is not good for reaction monitoring, and Boc has no good stability of Trt, which results in generation of racemic impurities

doi: 10.1136/bmjopen-2017-016028 179

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