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Also, vitamin B12 deficiency tends to come on very slowly, so people often go through a long period of being mildly deficient

The success of these agents in preclinical models and clinical trials suggests a promising future for multiagonists in the treatment of metabolic diseases, with the most recent glucose-dependent insulinotropic peptide receptor:glucagon-like peptide 1 receptor:glucagon receptor (GIPR:GLP-1R:GCGR) triagonists rivaling the efficacy of bariatric surgery

GLP-1 medications are relatively new, so long-term risks have not been seen at this time

Wiley, J

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