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Ferrous iron can be transported into the circulation from intestinal enterocytes and from hepatocytes which represent the major iron storage cells in the body

Randomized trials report 612 % body-weight loss at 56 weeks when Contrave is paired with lifestyle counseling (Wiley 2024)

126 Co-administration of warfarin (a substrate of CYP1A2, CYP2C9, and CYP3A4) and octreotide led to high INR levels in humans, which may be attributed to the increased warfarin exposure caused by octreotides inhibitory effect on CYP3A4

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All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA)