The difference between 1.8ml and 2.0ml bacteriostatic water when reconstituting a 10mg vial creates a 10% concentration variance
As we explained in the CY 2025 PFS final rule (89 FR 98237), this policy is intended to hold beneficiaries harmless in situations where the payment amount is calculated differently from the specified amount, and we believe this approach is consistent with the statutory language and appropriately reflects the differences in the statutory text of section 1847A(i)(5) of the Act, which sets forth the payment amount that is used to determine whether coinsurance should be adjusted, and section 1847A(i)(3)(A) of the Act, which sets forth the specified amount used to determine rebate amounts
Gopal Grandhige, MD, FACS, Board-Certified Surgeon Last Reviewed: July 11, 2026 The short answer is yes, a little, but not the way the ads promise
A sharp IM peak that clears in 36 hours provides less cumulative signaling than sustained SubQ levels maintained across 72+ hours
Statements Author contributions FW: Conceptualization, Data curation, Writing original draft, Writing review & editing
Temperature, light exposure, and water type all affect stability
