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Abstract Despite increasing evidence of oxidative stress in the pathophysiology of autism, most studies have not evaluated biomarkers within specific brain regions, and the functional consequences of oxidative stress remain relatively understudied

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Nevertheless, inborn errors of purine metabolism should be excluded in patients with uric acid overproduction, particularly in men with disease onset under the age of 25 to 30 years and in women with gout onset in the early menopause and not due to other defined etiology such as CKD or thiazide or loop diuretic use