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Phase III bioequivalence study showed comparable HbA1c, fasting glucose, post-prandial glucose, and weight outcomes vs the reference innovator

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Additional research reviewed in ScienceDirect highlighted differences in insulin sensitivity and energy utilization between single- and dual-agonist therapies

Long-acting agents (semaglutide weekly, dulaglutide, tirzepatide) produce continuous but physiologically attenuated gastric slowing because of tachyphylaxis at the gastric GLP-1 receptor [3]

In some patients, usually those with more severe physeal fractures, there is a risk that the growth plate is damaged and can result in abnormal growth of the bone after the fracture is healed