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Determination of tissue antioxidant capacity Hyperthyroid-induced rats exhibited pronounced disruptions in tissue redox balance, as evidenced by a significant reduction in TAC and a concomitant increase in MDA levels relative to the euthyroid control group (Table 5)

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Osteopontin (OPN) is a highly phosphorylated glycoprotein that exerts multiple functions outside of its role in bone mineralization via regulation of osteoclast function

Because they enter systemic circulation, they can alter hormone levels, increase IGF-1 (which may raise cancer risk in certain cases), and cause unwanted metabolic effects

It's not clear how low B12 levels lead to depression, but it might be linked to problems with chemical reactions in the brain