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Second, as CG-rich genes are preferentially regulated at the transcriptional elongation stage, this might give them a selective advantage of becoming rapidly upregulated on appropriate stimuli (Hargreaves et al., 2009

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This would seem to be a potentially fruitful area for further research since the major environmental risk factors for PDexposure to pesticides, trichloroethylene, and air pollutionare likely to have their effects on dopaminergic neurodegeneration via toxic effects of oxidative stress and inflammation 61

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To determine whether the pro-oxidant state prevented the reduction in Tbr2 + INPs, and effects of HIF1a expression in these cells, we examined Tbr2 and HIF1a co-localization in the SGZ of animals treated with MnTMPyP