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Clinical data shows MK-677 increases growth hormone levels by 89% and IGF-1 by 72% within four weeks, while maintaining these elevations throughout treatment

This effect is inconsistent and not the primary mechanism of any weight loss observed

doi:10.1371/journal.pone.0035683 62

The compound was never approved as a pharmaceutical treatment for obesity because the Phase 2 clinical trial results, while showing safety and modest efficacy, did not meet the threshold for drug registration