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216 In addition, PRMT4-catalyzed asymmetric dimethylarginine (ADMA) has been reported to bind to NOS as a ligand, leading to NOS dysfunction, resulting in decreased cerebral blood flow and aggravating AD, which can be reversed by inhibition of PRMT4

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This comparison helps clarify how AOD 9604 is positioned relative to upstream GH-axis modulators in experimental systems

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But Zontag points out that its hard to say from these findings alone