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Skin moisturization and elasticity were measured by a cutometer, wrinkle depth was quantified using an Antera 3D image system of the face, and clinical evaluations were performed by a dermatologist for skin softness, smoothness, firmness, and wrinkles using a standardized scoring system

doi: 10.1111/nph.19018 11 ChenK.ZhangM.BhandariB.MujumdarA

Journal of Neurochemistry, 97(2), 303309

Significant functional decline warrants immediate medical attentionthis includes new difficulty climbing stairs, rising from a chair without assistance, carrying groceries, or performing routine daily activities that were previously manageable