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Patients on semaglutide often experience early reductions in caloric intake and sometimes mild dehydration from GI side effects

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3.2.3 Downregulate expression of NF-B and upregulate expression of Nrf-2 NF-B regulated inflammatory responses and its activation lead to increased expression of pro-inflammatory cytokines, while nuclear factor-erythroid 2related factor 2 (Nrf-2) reduced the synthesis of inflammatory mediators by inhibiting the NF-B (Hegazy and El-Bedewy, 2010