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425 The ongoing phase III clinical trial (NCT04770220) aims to further validate these positive results regarding efficacy and safety in APOE4 homozygous individuals with early AD, with the study expected to continue until 2024

The depolarization and resulting activation of AMPA and NMDA receptors in the postsynaptic cell causes endocytosis of these receptors

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The earliest approved drug is Exenatide from Eli Lilly, launched in April 2005 and received orphan drug designation from the European Union

The Mechanism Behind THCV's Appetite Effects THCV acts as a CB1 receptor antagonist, which means it blocks certain cannabinoid receptors associated with appetite stimulation

10.1016/S0140-6736(10)60399-6 32 DasS.GuptaA