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While the majority of glutathione in cells is in the reduced form, GSH oxidation can occur resulting in the formation of GSSG or GSSP

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Primary CD4 + T cells infected with HIV-1 show markers of oxidative stress, such as a decreased GSH/GSSG ratio (Shytaj et al., 2020) and this elevated ROS may enhance LTR activation (Schreck et al., 1991)