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revealed that in an ISO-mediated model of myocardial infarction, direct overexpression of the Nrf2 gene enhanced GSH levels in cardiomyocytes and guarded cardiomyocytes against oxidative damage and lessened the occurrence of ferroptosis [202]

10.1111/j.1745-7254.2008.00889.x 73 WilczewskaA

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Model Overview Figure 1 shows the biochemical pathways in the hepatic cellular model used in this paper

An RCT in 36 patients with type 2 diabetes found that NAC (1,200 mg/day for 4 weeks) combined with a standard diabetes diet significantly reduced fasting glucose, HbA1c, and markers of oxidative stress compared to diet alone (Shahidi et al., J Diabetes Metab Disord, 2020) [56]

As expected the GSH levels rebound during the rest period, with the ELF GSH levels rising to about 250 M within the first 2 hours