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performed a study on primary culture of OFs obtained from GO patients and control subjects, demonstrating that superoxide radicals induced an increased proliferation of OFs from GO patients compared with control fibroblasts ( The hypothesis that oxidative stress contributes GO pathogenesis was also suggested by studies performed by Tsai et al

IL-10 protects against OPC ferroptosis by regulating lipid reactive oxygen species levels post stroke

In T2D patients (n = 25, age 2565), consumption of 1 g L-citrulline twice a day for 4 weeks reduces the T2D-induced increase in arginase activity and increases plasma nitrites, effects corroborated by improvement of ACh-induced relaxation in ex vivo mouse aortic rings incubated (24-h) in low or high glucose-containing media and increases in NO production in ECs treated with high glucose (Shatanawi et al., 2020)

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